Frustration-guided motion planning reveals conformational transitions in proteins
نویسندگان
چکیده
منابع مشابه
Frustration-guided motion planning reveals conformational transitions in proteins.
Proteins exist as conformational ensembles, exchanging between substates to perform their function. Advances in experimental techniques yield unprecedented access to structural snapshots of their conformational landscape. However, computationally modeling how proteins use collective motions to transition between substates is challenging owing to a rugged landscape and large energy barriers. Her...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics
سال: 2017
ISSN: 0887-3585
DOI: 10.1002/prot.25333